Assistant Professor Chihiro Takizawa, PhD, RN, in department of gerontological nursing/wound care management
Senescent cells, known for inducing SASP and chronic inflammation, may contribute to delayed wound healing in hard-to-heal wounds. This study analyzed gene expression in wound exudates from pressure injuries. CDKN1A, a marker of cellular senescence, was expressed in 96.3% of samples and positively correlated with SASP factors. Lower CDKN1A expression was linked to a higher wound area reduction rate, suggesting senescent cells in wound exudates may hinder wound healing.
Access the full paper here: https://pubmed.ncbi.nlm.nih.gov/39876615/